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1864年,诺贝尔以三硝酸丙三醇脂(硝酸甘油)为主要原料,制造出了安全炸药。安全炸药的工业化生产给诺贝尔带来了荣誉和金钱,使他得以创立科学界的最高奖项——诺贝尔奖。诺贝尔晚年患有严重的心脏病,医生曾建议他服用硝酸甘油以缓解心绞痛的发作,但诺贝尔拒绝了,因为早在研制安全炸药的实验过程中,诺贝尔就发现吸入硝酸甘油蒸气会引起剧烈的血管性头痛。1896年,诺贝尔因心脏病发作而逝世。硝酸甘油可以有效地缓解心绞痛,但它的作用机理困扰了医学家、药理学家百余年,直
In 1864, Nobel used glycerol trinitrate (nitroglycerin) as the main raw material to make safety explosives. The industrial production of safe explosives has brought Nobel the honor and money that enabled him to create the Nobel Prize, the highest award in the scientific community. Nobel suffered a serious heart disease later in life. Doctors advised him to take nitroglycerin to ease the onset of angina, but Nobel refused because early experiments with safe explosives led Nobel to find that inhaling nitroglycerin vapor causes Severe vascular headache. In 1896, Nobel died of a heart attack. Nitroglycerin can effectively relieve angina pectoris, but its mechanism of action has plagued medical scientists and pharmacologists for over a hundred years.