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目的 探讨多糖类药物对LAK细胞增殖功能的影响和抑瘤作用。方法 建立B16黑色素瘤小鼠模型 ,Ⅰ组瘤体周围皮下注射IL 2 ,Ⅱ组注射IL 2和人参多糖 ,Ⅲ组注射人参多糖 ,通过测量瘤重、瘤体积和抑瘤率观察其抑瘤作用 ;同时取小鼠脾细胞培养 ,1组加IL 2 ,2组加IL 2和人参多糖 ,3组加人参多糖 ,用台盼蓝染色 ,观察多糖类药物对LAK细胞增殖功能的影响。结果 人参多糖与IL 2联合体内应用抗肿瘤作用显著强于LAK细胞 (P <0 .0 5 ) ;人参多糖与IL 2联合体外培养表明 ,人参多糖能促进LAK细胞的增殖能力 (P <0 .0 5 )。结论 人参多糖与IL 2联合应用在体内抗肿瘤作用显著强于LAK细胞 ,在体外培养能促进LAK细胞的增殖能力
Objective To investigate the effects of polysaccharides on the proliferation of LAK cells and the antitumor effect. Methods The B16 melanoma mouse model was established. IL 2 was injected subcutaneously into the tumor in group Ⅰ, IL 2 and ginseng polysaccharide were injected into group Ⅱ, and ginseng polysaccharide was injected into group Ⅲ. The antitumor activity was observed by measuring tumor weight, tumor volume and tumor inhibition rate At the same time, mouse splenocytes were cultured. One group was given IL-2, the other two groups were treated with IL-2 and ginseng polysaccharides. Ginseng polysaccharides were added into the three groups, and the effect of polysaccharides on the proliferation of LAK cells was observed by trypan blue staining. Results The antitumor effect of polysaccharide combined with IL 2 in vivo was significantly stronger than that of LAK cells (P <0.05). The in vitro culture of Ginseng polysaccharides and IL 2 showed that ginseng polysaccharide could promote the proliferation of LAK cells (P <0. 0 5). Conclusion The combined application of polysaccharide and IL 2 in ginseng is significantly stronger than that in LAK cells in vivo and can promote the proliferation of LAK cells in vitro