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目的:探讨新型冠状病毒肺炎（COVID-19）疫情期间SLE患者的抑郁状况。方法:收集2020年8月16日至2020年9月2日来自新疆维吾尔自治区乌鲁木齐及各地州SLE患者和健康人群（对照组）信息，采用抑郁自评量表（SDS）、匹兹堡睡眠质量指数量表（PSQI）进行抑郁和睡眠质量评估。非正态分布数据用n M（n P25，n P75）表示，2组间连续变量比较采用秩和检验。连续变量采用Pearson相关性检验，等级变量或分类变量采用Spearman相关性检验。n 结果:SLE组抑郁患病率为41.9%（62/148）明显高于健康对照组32.1%（36/148），差异有统计学意义（n χ2=10.312，n P<0.01），SLE组睡眠障碍患病率为31.8%（47/148）明显高于健康对照组21.61%（32/148），差异有统计学意义（n χ2=3.885，n P=0.049）。VAS（n OR=1.366，n P<0.01），PSQI总分（n OR=1.198，n P<0.01）为SLE患者合并抑郁的危险因素。n 结论:疫情隔离期间SLE患者抑郁患病率较非疫情期间SLE患者高，疼痛、睡眠质量差为独立危险因素，需要积极关注SLE患者的心理状况。“,”Objective:To explore the depression of patients with systemic lupus erythematosus (SLE) during the coronavirus disease 2019 (COVID-19) pandemic.Methods:Patients with SLE and healthy subjects(control group) from August 16, 2020 to September 2, 2020 in Urumqi, Xinjiang were collected. The depression and sleep quality were assessed by Self rating Depression Scale (SDS) and Pittsburgh sleep quality index (PSQI). The nonparametric data were represented by median (quartile spacing), and the rank sum test was used to compare the continuous variables between the two groups. Pearson correlation test was used for continuous variables, and Spearman correlation test was used for rank variables or classified variables. Statistical product and service solutions.Results:The prevalence rate of depression in the SLE group (41.9%) was significantly higher than that in healthy control group (32.1%). The difference was statistically significant ( n χ2= 10.312, n P<0.01). The prevalence rate of poor sleep in the SLE group (31.8%) was significantly higher than that in healthy control group (21.6%). The difference was statistically significant(n χ2=3.885, n P=0.049). The total score of VAS (n OR=1.366, n P<0.01) , PSQI(n OR=1.198, n P<0.01) were the risk factor of depression in patients with SLE.n Conclusion:SLE patients have a higher prevalence of depression during pandemic quarantinee-period, pain and poor sleep quality are risk factors. We need to pay attention to the psychological status of SLE patients.