目的　探讨遗传因素在普通型偏头痛发生中的作用及该病的遗传方式。方法　以 2 7例普通型偏头痛患者为先证者 ,收集其一级和二级亲属的患病资料 ,采用零截尾泊松分布模型判断该病有无家庭聚集性 ,应用Penrose法和Li Mantel Gart法判断该病的遗传方式 ,应用PPAP软件估算该病的遗传度。结果　先证者一级亲属该病的患病率 >二级亲属 >一般人群 ,符合多基因遗传病的特点 ;Penrose法的结果也显示该病为多基因遗传病 ,其一级亲属的遗传度为 0 .935± 0 .0 98,二级亲属的遗传度为 0 .439± 0 .2 84,遗传度的加权平均值为 0 .82 4±0 .0 93。结论　普通型偏头痛是一种多基因遗传病 Objective To investigate the role of genetic factors in the development of common migraine and the genetic mode of the disease. Methods Twenty-seven patients with migraine were selected as probands. The prevalence of first-degree and second-degree relatives was collected. The zero-clump Poisson distribution model was used to determine whether there was familial aggregation. Penrose and Li Mantel Gart method to determine the genetic mode of the disease, the application of PPAP software to estimate the heritability of the disease. Results The first-degree relatives of probands had the prevalence of the disease> second-degree relatives> the general population, which was in line with the characteristics of polygenic inheritance. The results of Penrose also showed that the disease was polygenic disease with heritability Was 0.935 ± 0.0898, the second-degree relatives had a genetic degree of 0.399 ± 0.224, and the weighted average of heritability was 0.82 4 ± 0.93. Conclusion Common migraine is a polygenic disease