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目的:对比观察小剂量盐酸戊乙奎醚(长托宁)对产妇分娩镇痛、产程及母婴的影响。方法:选择要求分娩镇痛产妇100例,ASA分级Ⅰ~Ⅱ级,头盆不称、分娩潜伏期明显延长者不纳入研究。随机分为长托宁组50例和对照组50例(生理盐水组)。两组产妇均于第一产程宫口开大3 cm时实施连续硬膜外麻醉,硬膜外麻醉前产妇进入潜伏期即规律宫缩后,长托宁组肌肉注射盐酸戊乙奎醚、对照组注射生理盐水,观察并记录用药后两组产妇第一、第二及第三产程时间、胎心率、新生儿出生后1、5 min Apgar评分及产后出血量。结果:长托宁组第一产程短于对照组,差异有统计学意义(P<0.01);两组产妇第二、三产程、剖宫产率、新生儿窒息率、产后出血量差异无统计学意义(P>0.05)。结论:长托宁可有效地缩短第一产程时间从而缩短产程,降低了因产程延长而对母婴造成的不良影响。
OBJECTIVE: To compare the effects of low dose penehyclidine hydrochloride (PCP) on labor analgesia, labor process and maternal infant in labor. Methods: 100 cases of labor analgesia and ASA grade Ⅰ ~ Ⅱ were asked to do the labor analgesia, and were not included in the head basin. The prolonged labor latency was not included in the study. Randomly divided into 50 cases of penehyclidine group and 50 cases of control group (saline group). Both groups of maternal were in the first stage of labor to open a large cervix 3 cm continuous epidural anesthesia, epidural anesthesia before the entry into the incubation period of the law of contractions, the long Tuoning group intramuscular injection of penehyclidine hydrochloride, the control group The rats were injected with normal saline. The time of first, second and third stage of labor, fetal heart rate, 1,5-minute Apgar score and postpartum hemorrhage were observed and recorded. Results: There was no significant difference in the first stage of labor between the two groups in the second and third trimester of labor, cesarean section rate, neonatal asphyxia and postpartum hemorrhage Significance (P> 0.05). Conclusions: Penehyclidine can shorten the time of the first stage of labor effectively and shorten the course of labor, reducing the adverse effects on mothers and babies caused by prolonged labor.