作者应用静脉注射大剂量甲基强的松龙治疗2例骨髓纤维化,获得良好疗效,且无严重副作用。病例1 男,60岁,肝肿大右肋缘下6cm,脾肿大肋缘下10cm。贫血征,血红蛋白9g/dl,网织红细胞1.8%,血小板轻度减少为450×10~9/L,白细胞8.6×10~9/L 外周血有少量成红细胞(每100个白细胞有1个),中幼粒细胞16%;骨髓活检提示细胞呈过少状态伴网蛋白原纤维和巨核细胞增多。甲基强的松龙用量为30mg/kg,静注连用3日,以后20mg/kg,用4日,再减量直至血红蛋白达12g/dl 为止。每日 The authors applied intravenous bolus methylprednisolone treatment of 2 cases of myelofibrosis, with good results, and no serious side effects. Case 1 male, 60 years old, hepatomegaly right lower edge of 6cm, splenomegaly large 10cm. Anemia, hemoglobin 9g / dl, reticulocyte 1.8%, platelet mildly reduced to 450 × 10 ~ 9 / L, white blood cells 8.6 × 10 ~ 9 / L peripheral blood with a small amount of red blood cells (1 per 100 white blood cells) , 16% of the neutrophils; bone marrow biopsy prompted the cells were too few with retinal fibril and megakaryocytes increased. Methylprednisolone dosage 30mg / kg, intravenous 3 days, after 20mg / kg, with 4, and then down until hemoglobin up to 12g / dl so far. daily