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目的研究血浆基质金属蛋白酶-9(MMP-9)、血清血管假性血友病因子(vWF)浓度在急性脑梗死发病早期(<6 h)的变化。方法检测脑功能损害体征持续存在>1 h,年龄<75岁患者的MMP-9、vWF浓度,根据最终诊断区分脑梗死组及非梗死组,比较MMP-9、vWF浓度的变化。结果急性脑梗死早期外周血MMP-9、vWF水平即有升高,如果以MMP-9>160μg/L、vWF>150μg/L为标准对急性脑梗死早期(<6 h)进行诊断,发病4～6 h的敏感性和特异性为92.3%和92.9%。结论以MMP-9>160μg/L、vWF>150μg/L为标准对急性脑梗死发病后4 h诊断有较高的特异性和敏感性,值得临床推广。
Objective To investigate the changes of plasma matrix metalloproteinase-9 (MMP-9) and serum von Willebrand factor (vWF) in the early stage of acute cerebral infarction (<6 h). Methods The levels of MMP-9 and vWF in patients with signs of brain damage> 1 h and age <75 years were detected. The changes of MMP-9 and vWF levels were compared between the cerebral infarction group and the non-infarcted group according to the final diagnosis. Results The levels of MMP-9 and vWF in the peripheral blood of patients with acute cerebral infarction were elevated in the early stage of acute cerebral infarction. If the levels of MMP-9> 160 μg / L and vWF> 150 μg / L were used as the criteria, the early stage of acute cerebral infarction (<6 h) The sensitivity and specificity of ~ 6 h were 92.3% and 92.9%. Conclusion MMP-9> 160μg / L and vWF> 150μg / L are the standard for diagnosis of acute cerebral infarction 4h after the onset of high specificity and sensitivity, worthy of clinical promotion.