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目的:研制隐丹参酮微乳,并评价其质量。方法:通过滴定法绘制伪三元相图,筛选微乳处方;采用反相高效液相色谱法(RP-HPLC)测定隐丹参酮的含量,并以其外观、粒径及分布、含量为指标考察微乳的稳定性。结果:优选的处方聚氧乙烯氢化蓖麻油(RH40)、无水乙醇(Ethanol)、十四酸异丙酯(IPM)、水(Water)的比例为(3:1:0.3:9),所制微乳的外观均一透明,平均粒径4.233μm,载药量944.0μg·mL~(-1)。结论:隐丹参酮微乳性质稳定,可显著增加隐丹参酮在水中的溶解度。
Objective: To develop cryptotanshinone microemulsion and evaluate its quality. Methods: Pseudo-ternary phase diagrams were drawn by titration to screen microemulsion prescriptions. The content of cryptotanshinone was determined by reversed-phase high performance liquid chromatography (RP-HPLC) and its appearance, particle size, distribution and content were used as indicators. Microemulsion stability. Results: The preferred prescription polyoxyethylene hydrogenated castor oil (RH40), anhydrous ethanol (Ethanol), isopropyl myristate (IPM), water (Water) ratio is (3:1:0.3:9). The appearance of the microemulsion was uniform, the average particle size was 4.233 μm, and the drug loading was 944.0 μg·mL-1. Conclusion: The properties of cryptotanshinone microemulsion are stable, which can significantly increase the solubility of cryptotanshinone in water.