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目的探讨白眉蛇毒血凝酶结合泮托拉唑应用于上消化道出血的临床效果。方法 76例消化道出血患者,随机分为观察组和对照组,各38例。观察组患者给予白眉蛇毒血凝酶结合泮托拉唑治疗,对照组患者单独给予泮托拉唑治疗。观察两组患者用药后的临床有效率、止血时间及不良反应发生情况。结果观察组患者显效20例,有效16例,无效2例,总有效率为94.74%,对照组患者显效14例,有效10例,无效14例,总有效率为63.16%,观察组总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组患者平均止血时间为(20.0±4.7)h,对照组平均止血时间为(40.0±7.2)h,观察组止血时间少于对照组,差异具有统计学意义(P<0.05)。结论白眉蛇毒血凝酶结合泮托拉唑应用于上消化道出血的临床效果较单独给予泮托拉唑治疗有效率高,且不良反应少,值得临床广泛应用。
Objective To investigate the clinical efficacy of the combination of panoplysulphala rhinocozyme and pantoprazole in upper gastrointestinal hemorrhage. Methods 76 patients with gastrointestinal bleeding were randomly divided into observation group and control group, 38 cases each. Patients in the observation group were treated with white eyebrow hemagglutinin combined with pantoprazole, and patients in the control group were treated with pantoprazole alone. The clinical efficacy, bleeding time and adverse reactions of the two groups were observed after treatment. Results In the observation group, 20 cases were markedly effective, 16 cases were effective, 2 cases were ineffective and the total effective rate was 94.74%. In the control group, 14 cases were markedly effective, 10 cases were effective and 14 cases were ineffective. The total effective rate was 63.16% Higher than the control group, the difference was statistically significant (P <0.05). The average hemostasis time in the observation group was (20.0 ± 4.7) h, the mean bleeding time in the control group was (40.0 ± 7.2) h, and the bleeding time in the observation group was less than that in the control group. The difference was statistically significant (P <0.05). Conclusion The clinical efficacy of panax phleopi combined with pantoprazole in the treatment of upper gastrointestinal hemorrhage is higher than that of the pantoprazole given alone, with less side effects. It is worth widely clinical application.