目的探讨肝源性糖尿病的发生特点、发病机制、诊断和治疗。方法回顾性分析我院40例肝源性糖尿病患者的临床诊治。结果本组40例患者中,17例血糖明显好转,空腹血糖降至7.0mmol/L以下(42.5%);19例无明显好转(47.5%);3例治疗前血糖水平较高者治疗后空腹血糖虽仍>11.1mmol/L,但较治疗前好转,血糖明显下降(7.5%);1例因口服甲胺磷后多器官功能衰竭死亡(2.5%)。结论肝源性糖尿病发病机制复杂多样,与多个因素有关,其治疗要兼顾肝病和糖尿病,重点考虑治疗原发病,加强护肝治疗,去除升糖因素,对于血糖明显升高和肝功能损害较严重的患者,尽量早期使用胰岛素。 Objective To investigate the occurrence, pathogenesis, diagnosis and treatment of liver-derived diabetes mellitus. Methods The clinical diagnosis and treatment of 40 cases of liver-derived diabetes in our hospital were retrospectively analyzed. Results Among the 40 patients in this group, blood glucose was significantly improved in 17 patients and fasting blood glucose was reduced to below 7.0mmol / L (42.5%). No significant improvement was observed in 19 patients (47.5%). Three fasting blood glucose Although blood glucose was still> 11.1mmol / L, but better than before treatment, blood glucose decreased significantly (7.5%); 1 case died of multiple organ failure after oral methamidophos (2.5%). Conclusions The pathogenesis of liver-derived diabetes is complex and diverse, which is related to many factors. The treatment should focus on liver disease and diabetes. The treatment should focus on the treatment of the primary disease, strengthen the protection of liver and remove the factors that cause glycemic excretion, and significantly increase the blood glucose and liver damage Serious patients, try to use insulin early.