Tumoral calcinosis is a kind of rare non-neoplastic lesions, which presents a large number of nodular lesions of calcium salt around the large joint, with surrounding tissues not invaded. There are gravel-like tissues in the well-encapsulated lesions. The etiology of tumoral calcinosis is unknown now, which may be related to the genetic factors, collagen tissue reaction, cholesterosis, immunoreaction, injuries and disturbance of calcium and phosphorus. The X-ray iflms show high-density and irregular masses. At present, the early resection is the main treatment method. We successfully performed an operation on a patient with tumoral calcinosis masses in the popliteal fossa, which turned out to be tumoral calcinosis after the surgery.