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目的:了解江门地区职业女性高危型人乳头瘤病毒(HPV)的感染状况,为宫颈癌防治提供理论依据。方法:2008年10月～2009年10月期间,采取高危型HPV病毒基因多重荧光PCR检测技术对江门地区1 300名职业女性进行免费检查,并对高危型HPV感染者的年龄阶段、取材生理周期、宫颈情况进行分析。结果:1 300名女性共检出高危型HPV阳性者103例,平均年龄为(39±9)岁,感染率为7.92%;其中20岁～、31岁～、46岁～、61岁～年龄组间,31岁～年龄组的感染率最高9.50%(67/705),它们之间的差异有统计学意义(P<0.05);宫颈情况方面,发生Ⅲ度宫颈糜烂者感染率最高31.58%(12/38),它们之间的差异有统计学意义(P<0.05);高危性HPV感染者取材生理周期的分布中,黄体期、排卵期、卵泡期和绝经期之间的差异没有统计学意义(P>0.05)。结论:江门地区职业女性高危型HPV感染率相对较低,高危型HPV的感染与年龄阶段、宫颈糜烂程度密切相关,应该积极开展高危型HPV的筛查工作,有效降低该人群宫颈癌的发生率和致死率。
Objective: To understand the infection status of high risk human papillomavirus (HPV) in professional women in Jiangmen area and to provide a theoretical basis for the prevention and treatment of cervical cancer. Methods: From October 2008 to October 2009, 1,300 professional women in Jiangmen area were examined free of risk by multi-fluorescent PCR detection of high-risk HPV. The age, Cervical conditions were analyzed. Results: A total of 1 300 women were detected in 103 cases of high-risk HPV-positive patients, with an average age of (39 ± 9) years and an infection rate of 7.92%. Among them 20 years old, 31 years old, 46 years old, 61 years old ~ Among the groups, the infection rate in the 31-year-old group was the highest (9.50%, 67/705), the difference was statistically significant (P <0.05); in the cervical condition, the infection rate of Ⅲ degree cervical erosion was the highest (31.58% (12/38), the difference between them was statistically significant (P <0.05). There was no statistical difference in the luteal phase, ovulation period, follicular phase and menopause among the high-risk HPV infected persons Significance (P> 0.05). Conclusion: The prevalence of high-risk HPV in occupational women in Jiangmen area is relatively low. The infection rate of high-risk HPV is closely related to the age and the extent of cervical erosion. Screening of high-risk HPV should be actively carried out to effectively reduce the incidence of cervical cancer in this population And lethality.