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目的：观察骨形成蛋白（ＢＭＰ）在骨折愈合过程中的基因表达及发挥作用方式．方法：在建立兔颌骨骨折愈合模型的基础上，用免疫组织化学及原位杂交的方法在骨折愈合的不同时间分别检测ＢＭＰ表达产物和ＢＭＰ２ｍＲＮＡ转录水平．结果：在骨折愈合早期由受创伤的骨基质释放的ＢＭＰ在骨膜及骨断端骨髓中的骨诱导中发挥着重要的作用；此外，受到诱导刺激的细胞在分化为具有成骨及成软骨能力的细胞的同时，也具有合成及分泌ＢＭＰ的能力，这种能力保证了正常骨组织的形成．结论：本实验结果进一步证实了ＢＭＰ骨诱导贯穿于骨折愈合整个过程，ＢＭＰ在骨折愈合中发挥着重要的作用
Objective: To observe the gene expression of bone morphogenetic protein (BMP) during fracture healing and the mode of action. Methods: Rabbit mandibular fracture healing model was established. The expression of BMP2 mRNA and BMP2 mRNA were detected by immunohistochemistry and in situ hybridization at different times of fracture healing. RESULTS: BMP released from the traumatic bone matrix early in the fracture healing plays an important role in the osteoinduction in the periosteum and the bone marrow of the broken ends; in addition, the cells that are stimulated to induce differentiation into osteogenic and chondrogenic Of cells, but also has the ability to synthesize and secrete BMP, this ability to ensure the formation of normal bone tissue. CONCLUSION: The results of this experiment further confirmed that bone morphogenetic protein (BMP) induces the whole process of fracture healing. BMP plays an important role in fracture healing