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目的探究老年糖尿病患者检测GHb及血小板参数的临床意义。方法糖化血红蛋白采用免疫比浊法用全自动生化分析仪OLYMPUS640测定,平均血小板体积、血小板分布宽度、血小板计数用希森美康生产的XE-2100全自动血细胞分析仪测定。结果糖尿病病变组的糖化血红蛋白、平均血小板体积和血小板分布宽度均高于健康对照组,健康对照组的血小板计数与糖尿病患者二组间无明显差别;有微血管病变组的糖尿病患者平均血小板体积、血小板分布宽度明显高于无微血管病变组。结论糖尿病患者的糖化血红蛋白越高,发生微血管病变的可能性就越高,血小板参数的改变与糖尿病微血管病变的形成关系密切。
Objective To investigate the clinical significance of detecting GHb and platelet parameters in senile patients with diabetes mellitus. Methods Glycosylated hemoglobin was measured by automatic turbidimetry using an automatic biochemical analyzer OLYMPUS640. The mean platelet volume, platelet distribution width and platelet count were measured by XE-2100 automatic hematology analyzer manufactured by Sysmex. Results In diabetic patients, the values of HbA1c, platelet volume and platelet distribution were all higher than those in healthy control group. There was no significant difference in platelet count between healthy controls and diabetic patients. The mean platelet volume, platelet count, Distribution width was significantly higher than those without microvascular disease group. Conclusion The higher the HbA1c in diabetic patients, the higher the possibility of microvascular disease occurs. The change of platelet parameters is closely related to the formation of diabetic microangiopathy.