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目的探讨地诺前列酮栓联合缩宫素在过期妊娠引产中的应用效果。方法选取三河市妇幼保健院产科2015年3月—2016年11月收治的过期妊娠患者80例,按治疗方法的不同分为单一组和联合组,各40例。单一组患者给予缩宫素引产治疗,联合组患者给予缩宫素联合地诺前列酮栓引产治疗。比较两组患者治疗前后Bishop评分、产妇分娩情况(产后出血量、72 h临产率、总产程)及分娩结局(剖宫产、阴道助产、自然分娩、新生儿窒息)。结果联合组患者Bishop评分高于单一组(P<0.05)。联合组患者产后出血量少于单一组,72 h临产率高于单一组,总产程低于单一组(P<0.01)。两组患者阴道助产率及新生儿窒息发生率比较,差异无统计学意义(P>0.05);联合组患者剖宫产率低于单一组,自然分娩率高于单一组(P<0.05)。结论采用地诺前列酮栓联合缩宫素在过期妊娠引产患者中的应用效果良好,可有效促进患者宫颈成熟,减少术后出血量,提高自然分娩率,缩短产程,且用药方便。
Objective To investigate the effect of dinoprostone suppository combined with oxytocin in induction of labor during pregnancy. Methods 80 cases of obstetric patients from March 2015 to November 2016 in Sanhe MCH hospital were divided into single group and combined group according to the different treatment methods, 40 cases in each group. A single group of patients given oxytocin induction therapy, combined group of patients given oxytocin and dirprodum suppository treatment. Bishop score, maternal childbirth (postpartum hemorrhage, 72-hour labor, total labor) and delivery outcomes (cesarean section, vaginal delivery, spontaneous delivery, neonatal asphyxia) were compared between the two groups before and after treatment. Results The Bishop score of combined group was higher than that of single group (P <0.05). The amount of postpartum hemorrhage in the combined group was less than that in the single group, and the 72-hour labor rate was higher than that of the single group and the total labor was lower than that of the single group (P <0.01). The incidences of vaginal delivery and neonatal asphyxia in the two groups were not significantly different (P> 0.05). The cesarean section rate in the combined group was lower than that in the single group, and the rate of spontaneous delivery was higher than that in the single group (P <0.05) . Conclusion The application of dinoprostone suppository combined with oxytocin is effective in patients with induced abortion due to prolonged pregnancy, which can effectively promote cervical maturation, reduce the amount of postoperative bleeding, increase the rate of natural childbirth, shorten the birth process and facilitate the administration.