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目的 :探讨血浆高敏感 C反应蛋白 (hs- CRP)和淀粉样物质 A(SAA)与冠状动脉病变程度和病变活动性之间的关系。 方法 :分析 94例冠状动脉造影患者的临床资料 ,并采用乳胶增强速率散射比浊法测定患者循环血中 hs- CRP与 SAA水平。 结果 :临床诊断急性冠状动脉综合征患者血浆 hs- CRP和 SAA水平为 (1 6 .34± 1 6 .0 2 )和 (9.4 6± 6 .97) mg/ L ,明显高于正常对照组的 (1 .0 7± 1 .1 2 )和 (1 .2 4± 1 .1 1 ) m g/ L (P<0 .0 1 ) ;稳定型心绞痛组为 (2 .76± 2 .31 )和 (2 .85± 2 .1 3) mg/ L ,与对照组间无显著性差异 ;中、重度病变 ,单支、双支、三支病变及 Gensini积分 2 1～ 4 0分者 hs- CRP和 SAA水平明显高于对照组(P<0 .0 5 ,P<0 .0 1 )。结论 :冠心病的发生、发展过程中存在炎症反应 ;血浆 hs- CRP和 SAA水平可作为炎症标志物反映冠状动脉炎症状况 ,对急性冠状动脉综合征的判断有一定价值
Objective: To investigate the relationship between plasma high sensitive C-reactive protein (hs-CRP) and amyloid A (SAA), the degree of coronary artery lesion and lesion activity. Methods: The clinical data of 94 patients with coronary angiography were analyzed. The levels of hs-CRP and SAA in circulating blood were measured by latex enhanced rate nephelometry. Results: The plasma levels of hs-CRP and SAA in patients with acute coronary syndrome were (16.36 ± 16.22) and (9.46 ± 6.97) mg / L, respectively, which were significantly higher than those in the control group (1.70 ± 1.12) and (1.2.4 ± 1.1.1) mg / L, respectively (P <0.01). The patients in stable angina group were (2.76 ± 2.31) and (2.85 ± 2.13) mg / L, no significant difference between the control group; moderate and severe lesions, single, double, three lesions and Gensini score 21 ~ 40 hs- CRP And SAA levels were significantly higher in the control group (P <0.05, P <0.01). Conclusion: There is an inflammatory reaction during the development of coronary heart disease. The levels of hs-CRP and SAA in plasma can be used as inflammatory markers to reflect the inflammation of coronary artery and have some value in judging acute coronary syndrome