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羟基磷灰石(HAP)由于其良好的生物相容性及骨诱导作用而被广泛应用于生物复合材料中。但是,其本身容易聚集,与聚合物之间相容性差,会导致复合材料的力学性能和生物学性能下降。在HAP表面改性既可以有效防止颗粒间的聚集,增强其与基体间的相互作用,同时,还可以通过接上具有特殊功能的聚合物,赋予HAP新的用途。本文综述了羟基磷灰石的表面改性的3种方法,包括偶联剂、酯化反应和接枝聚合物,并介绍了这些方法对HAP性能的影响。
Hydroxyapatite (HAP) is widely used in biological composites due to its good biocompatibility and osteoinduction. However, it is easy to aggregate itself and has poor compatibility with the polymer, which leads to the decrease of the mechanical and biological properties of the composite. HAP surface modification can effectively prevent the aggregation of particles to enhance the interaction with the matrix, but also can be connected to have a special function of the polymer, to give HAP new uses. This review summarizes three methods for surface modification of hydroxyapatite, including coupling agents, esterification and graft polymers. The effects of these methods on the performance of HAP are also introduced.