乳腺癌转移抑制基因1(BRMS1)是2000年在乳腺癌细胞中发现的肿瘤转移抑制基因,研究发现其在多种恶性肿瘤中具有抑制肿瘤细胞转移的能力,可明显减少转移灶的发生,但其具体作用机制仍不清楚。对BRMS1基因的深入研究必将有助于对肿瘤转移的早期诊断及治疗,本文就BRMS1的基因结构、蛋白功能及其与肿瘤的关系、作用机制等予以综述。 Breast cancer metastasis suppressor gene 1 (BRMS1) is a tumor metastasis suppressor gene found in breast cancer cells in 2000. It has been found that BRMS1 has the ability of inhibiting the metastasis of tumor cells in a variety of malignant tumors and can significantly reduce the incidence of metastases Its specific mechanism of action is still unclear. In-depth study of BRMS1 gene will contribute to the early diagnosis and treatment of tumor metastasis. In this paper, we review the gene structure, protein function and its relationship with tumor, mechanism of BRMS1 and so on.