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肾上腺机能初现是肾上腺的青春期 ,它是指自 6～ 8岁左右肾上腺开始分泌肾上腺雄激素并逐渐增加的过程 ,目前认为肾上腺机能初现和性腺机能初现是独立的、分开的两个成熟过程。 3 β 羟类固醇脱氢酶和 17α 羟化酶 /17,2 0 裂解酶 (P45 0C17)在肾上腺机能初现调控中起着重要的作用 ,特别是P45 0C17丝氨酸磷酸化的激素调控 ,将有望揭开肾上腺机能初现的调控机制 ,但是到目前为止 ,对肾上腺机能初现的作用和机制还未完全清楚。该文就国外对这一研究领域 ,包括肾上腺机能初现的定义、作用和调控机制作一简要介绍。
The adrenal function is adrenal adolescence, it refers to the adrenal began to secrete adrenal and 6 ~ 8 years old and gradually increase the process, now that adrenal function and gonadal function appear early independent, separate two mature process. 3 beta hydroxysteroid dehydrogenase and 17 alpha hydroxylase / 17,2 0 lyase (P45 0C17) plays an important role in the regulation of adrenal function, especially the hormone regulation of P45 0C17 serine phosphorylation, Adrenal gland function of the early regulatory mechanism, but so far, the advent of the adrenal function of the role and mechanism is not yet fully understood. This article gives a brief introduction of the foreign countries in this research area, including the definition, function and regulatory mechanism of adrenal function.