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早知高密度脂蛋白(HDL)能将外周组织的胞内胆固醇转至胞外,继而由HDL携带至肝脏进行分解,然后排泄至体外.HDL的这种“逆向胆固醇转运”可能是HDL抗动脉粥样硬化的机理之一.近年来,一些研究表明HDL将胆固醇从细胞内转至胞外的作用是通过细胞表面专一性、高亲和力的HDL受体而实现的,HDL受体的数目似乎随着胞内胆固醇水平的上升而增加.弄清HDL受体的结构与功能,必然会促进和完善对HDL代谢通路的认识,在动脉粥样硬化的防治上有着极其重大的意义. 一、HDL受体的生物学特征已发现人的肝细胞、成纤维细胞、动脉平滑肌细
It has been known that high-density lipoprotein (HDL) can turn the intracellular cholesterol in the peripheral tissues to the extracellular state, which is then carried by the HDL to the liver for decomposition and then excreted to the body. This “reverse cholesterol transport” In recent years, some studies have shown that the role of HDL in the transfer of cholesterol from intracellular to extracellular is achieved through cell-surface-specific and high-affinity HDL receptors. The number of HDL receptors seems to be With the rise of intracellular cholesterol levels increased.Classification of HDL receptor structure and function, will inevitably promote and improve the understanding of HDL metabolic pathway, prevention and treatment of atherosclerosis has a very significant significance.A, HDL The biological characteristics of the receptor have been found in human liver cells, fibroblasts, smooth muscle arteries