目的　探讨晚发性维生素K缺乏症与维生素D缺乏性佝偻病的相关性。方法　回顾分析 42例晚发性维生素K缺乏症患儿的临床表现及辅助检查。结果　 42例晚发性维生素K缺乏症患儿中 39例有颅内出血 ,3例表现为全身散在出血点 ,全部病例均伴有维生素D缺乏性佝偻病的早期症状。其中 2例维生素D缺乏性手足搐搦症所致惊厥患儿病初头部CT检查未见异常 ,于惊厥反复发作后始出现颅内出血症状、体征及头部CT异常改变。结论　晚发性维生素K缺乏症与维生素D缺乏性佝偻病常同时并存 ,维生素D缺乏性手足搐搦症所致惊厥可诱发或加重晚发性维生素K缺乏症的颅内出血 Objective To investigate the relationship between vitamin K deficiency and vitamin D deficiency rickets. Methods Retrospective analysis of 42 cases of late onset vitamin K deficiency in children with clinical manifestations and laboratory tests. Results Of the 42 children with delayed vitamin K deficiency, 39 had intracranial hemorrhage and 3 showed systemic scattered bleeding. All patients were accompanied by early symptoms of vitamin D deficiency rickets. Two cases of convulsions caused by vitamin D-deficient tetany disease convulsions in children with early head CT examination showed no abnormalities, recurrent seizures after onset of intracranial hemorrhage symptoms, signs and head CT abnormalities. Conclusion Late onset vitamin K deficiency and vitamin D deficiency rickets often coexist, convulsions caused by vitamin D deficiency tetany can induce or aggravate late onset of vitamin K deficiency intracranial hemorrhage