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目的探讨赖氨葡锌颗粒治疗小儿急性腹泻的临床疗效。方法选取2013年10月—2015年3月东营市垦利县人民医院收治的急性腹泻患儿114例,按随机数字表法分为对照组59例与观察组55例。对照组患儿予以综合治疗,观察组患儿在对照组基础上加用赖氨葡锌颗粒治疗。观察两组患儿发热消失时间、呕吐消失时间、腹泻消失时间、临床疗效、腹泻发生情况及不良反应发生情况。结果观察组患儿发热消失时间、呕吐消失时间、腹泻消失时间短于对照组,总有效率高于对照组,差异有统计学意义(P<0.05);治疗后30、60、90d观察组患儿腹泻发生率低于对照组,差异有统计学意义(P<0.05),治疗后90d观察组患儿重型腹泻发生率低于对照组,差异有统计学意义(P<0.05);两组患者均未发生严重不良反应。结论赖氨葡锌颗粒治疗小儿急性腹泻的临床疗效显著,可改善患儿临床症状,且不良反应少。
Objective To investigate the clinical efficacy of lysine-glucose-zinc granules in the treatment of children with acute diarrhea. Methods 114 cases of acute diarrhea admitted to Kenli County People’s Hospital of Dongying City from October 2013 to March 2015 were divided into control group (n = 59) and observation group (n = 55) according to random number table. Control children with comprehensive treatment, children in the observation group on the basis of the control group plus lysine glufosinate granules treatment. Two groups of children with fever disappear time, vomiting disappear time, diarrhea disappear time, clinical efficacy, the occurrence of diarrhea and adverse reactions. Results The disappearance time, vomiting disappearance time and disappearance of diarrhea in observation group were shorter than those in control group, and the total effective rate was higher than that in control group (P <0.05). At 30, 60, and 90 days after treatment, The incidence of diarrhea in children was lower than that in the control group (P <0.05). The incidence of severe diarrhea in the observation group was lower than that of the control group 90 d after treatment (P <0.05) No serious adverse reactions occurred. Conclusion The clinical efficacy of lysine glufosinate granules in the treatment of children with acute diarrhea is significant, which can improve the clinical symptoms of children with less adverse reactions.