已有报道,红霉素可引起QT间期延长及扭转型室性心过速.为评价性别及年龄对红霉素引起心脏不良反应的影响,Drici等首先对美国食品及药物管理局(FDA)1970～1996年收集的红霉素心脏不良反应事件进行分析,然后建立离体灌注兔心体外实验模型以证实对QT间期影响的性别差异.1970～1996年FDA共收到红霉素引起心律失常报告346例,其中未明确性别者35例,男性110例,女 It has been reported that erythromycin can cause prolongation of the QT interval and torsades de pointes.To evaluate the impact of gender and age on erythromycin-induced cardiac adverse effects, Drici et al first performed a review on the FDA (Food and Drug Administration) ) Collected from 1970 to 1996 were analyzed for erythromycin-induced cardiac adverse events and then an in vitro experimental model of rabbit perfusion was established to confirm the gender differences in the QT interval. From 1970 to 1996, the FDA received erythromycin Arrhythmia was reported in 346 cases, of which 35 cases were unspecified and 110 cases were male