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本文报道了α干扰素(IFN-α)治疗慢性乙型肝炎过程中和治疗后产生的自身抗体和自身免疫反应情况。研究对象为32例HBsAg阳性的慢性乙型肝炎患者。其中17例HBeAg和乙型肝炎病毒(HBV)DNA均阳性的患者每次肌肉注射4.5MU重组IFN-α_(2a),每周3次共4个月;15例抗-HBe和HBV DNA阳性患者每次肌肉拄射5MU/m~2淋巴细胞IFN-α,每周3次共6个月。在治疗过程中及治疗终止后12个月内,对患者作常规的血清生化测定并检测HBV标志。患者血清保存于-20℃,用间接免疫荧光
This article reports the autoantibodies and autoimmune responses generated during and after treatment of interferon-alpha (IFN-α) in patients with chronic hepatitis B. The subjects were 32 HBsAg-positive chronic hepatitis B patients. Of the 17 patients with positive HBeAg and HBV DNA, 4.5 MU of recombinant IFN-α_ (2a) were intramuscularly injected three times a week for 4 months. Fifteen patients with positive anti-HBe and HBV DNA Each muscle injection of 5MU / m ~ 2 lymphocyte IFN-α, 3 times a week for a total of 6 months. During the course of treatment and within 12 months after termination of treatment, the patient was subjected to routine serum biochemical assays and HBV markers. Patient sera were stored at -20 ° C with indirect immunofluorescence