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目的 观察四川地区 2型糖尿病 (DM )患者、糖耐量低减 (IGT)者及糖尿病血缘亲属的胰岛 β细胞功能的变化 ,包括血中胰岛素原 (PI)水平的变化及其意义。 方法 采用特异性胰岛素(I)、C肽 (CP)和人胰岛素原放射免疫分析试剂盒 (均为美国Linco公司产品 )测定了糖耐量正常(NGT)对照者 (A组 ,49例 )、2型DM血缘亲属NGT者 (B组 ,5 2例 )、IGT/空腹血糖升高 (IFG)者 (C组 ,33例 )和新诊断的 2型DM患者 (D组 ,81例 )的空腹及试餐后 2小时上述三种激素的浓度 ,进行了各组内肥胖和非肥胖两个亚组的比较 ,以及各大组间的对比分析。结果 (1)各组内三种激素在肥胖亚组均比非肥胖亚组高 ;(2 )排除了肥胖因素 ,I及CP在IGT/IFG组最高。在DM组有下降趋势 ,但三种激素的空腹值仍高于对照组和亲属组 ;(3)无论肥胖或非肥胖亚组 ,PI从A→B→C→D组呈递增趋势 ,在D组无下降趋势 ,仍继续增高 ;(4 )以PI/I及PI/CP比值 (% )进行组间比较 ,发现无论空腹抑餐后 ,均以DM组最高 ;(5 )以大于A组PI/I及PI/CP比值的x± 2s为判断标准 ,发现“不成比例”的PI/I增高者之检出率在A、B、C及D组分别为 6 .1%、9.6 %、2 7.3 %及 6 1.7% ;以PI/CP为参数则各组分别为 10 .2 %、32 .7%、30 .3 %和 44 .4%。结论 “不成比例”的PI分泌增加是 β?
Objective To observe the changes of pancreatic β-cell function in patients with type 2 diabetes mellitus (DM), impaired glucose tolerance (IGT) and relatives of diabetic patients in Sichuan Province, including the changes of blood levels of proinsulin (PI) and its significance. Methods The patients with normal glucose tolerance (NGT) (control group A, n = 49), 2 patients (group A, n = 2) were treated with specific insulin (I), C peptide (CP) and human proinsulin radioimmunoassay kit Type 2 DM patients (group B, n = 52), patients with IGT / fasting plasma glucose (group C, 33 cases) and newly diagnosed type 2 DM patients (group D, n = 81) The levels of the above three hormones at two hours after the meal test were compared between the two subgroups of obesity and non-obesity, as well as the comparative analysis among the major groups. Results (1) The three hormones in each group were higher in the obese subgroup than in the non-obese subgroup. (2) Obesity was excluded, and the I and CP were the highest in the IGT / IFG group. In the DM group there is a downward trend, but the fasting value of the three hormones is still higher than that of the control group and the relatives group; (3) The PI shows an increasing trend from A → B → C → D in the obese or non-obese subgroup, (4) PI / I and PI / CP ratio (%) were compared between groups and found that both fasting and deprivation were highest in DM group; (5) / I and x ± 2s of the PI / CP ratio were the criteria for determining the detection rate of “disproportionately high” PI / I in the groups A, B, C and D, respectively, at 6.1%, 9.6%, 2 7.3%, and 6 1.7%, respectively. The groups with PI / CP as the parameters were 10.2%, 32.7%, 30.3% and 44.4% respectively. Conclusions “Proportional” increase in PI secretion is β?