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本实验提示新鲜人肝匀浆在体外可将双呋啶活化为具有抗癌活性的氟脲嘧啶。活化产物经紫外光谱测定,于265nm 处出现一吸收峰,与氟脲嘧啶的特征吸收峰吻合。温育60分钟,氟脲嘧啶含量达0.0061g/L。未加肝匀浆对照管氟脲嘧啶含量几乎测不出。溴液褪色试验阳性。金黄色葡萄球菌抑菌试验阳性。本实验证明猪肝匀浆与人肝匀浆同样具有潘化双呋啶的作用,并为体内活化的抗癌药的体外药敏试验提供了前提条件。
This experiment suggests that fresh human liver homogenate can be activated in vitro dual-furidine with anticancer activity of fluorouracil. Activated product by UV spectroscopy, an absorption peak at 265nm, and the characteristics of fluorouracil absorption peak. After incubation for 60 minutes, the content of fluorouracil reached 0.0061 g / L. Unfilled liver homogenate control tube fluorouracil content almost undetectable. Bromine solution fade test positive. Staphylococcus aureus antibacterial test was positive. This experiment proved that the porcine liver homogenate and human liver homogenate also have the role of panidine, and in vitro activation of anti-cancer drugs in vitro susceptibility testing provides the preconditions.