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肝脏是人体内最重要的器官之一,具有强大的再生能力。肝再生的调控机制非常复杂,众多因子参与其中,但大多数因子,类似肝细胞生长因子(HGF)、表皮生长因子(EGF)都不具备肝细胞作用的特异性。近年来,本实验室从新生小牛的肝脏中分离得到了能够特异性地促进肝细胞增殖、促进70%肝切除小鼠肝再生的物质并将其命名为HPPCn。因此,结合本实验室的工作对肝刺激物(HSS)、肝再生增强因子(ALR)、HPS、HPPCn等具有肝特异性作用的生物活性肽的研究进展以及相互之间的异同加以综述。
The liver is one of the most important organs in the body and has a strong regenerative capacity. Regulatory mechanism of liver regeneration is very complex, many factors involved, but most of the factors, such as hepatocyte growth factor (HGF), epidermal growth factor (EGF) do not have the specificity of the role of liver cells. In recent years, our laboratory isolated from the newborn calf liver can be specific to promote liver cell proliferation and promote liver regeneration in 70% of liver resected mice substance and named HPPCn. Therefore, the research progress and the similarities and differences between bioactive peptides with hepatic specificity such as liver stimulator (HSS), liver regeneration augmentation factor (ALR), HPS, HPPCn and so on are reviewed in this lab.