论文部分内容阅读
目的 探讨三氧化二砷（Ａｓ２Ｏ３） 对小鼠生殖作用的影响。方法 采用小鼠卵母细胞体外培养、体外受精的方法研究Ａｓ２Ｏ３ 对卵母细胞成熟和体外受精的影响。结果 Ａｓ２Ｏ３ 对小鼠卵母细胞生发泡破裂、超排卵的卵母细胞数目没有影响， 但可以抑制卵母细胞第一极体的释放， 降低体外受精率和卵母细胞的存活率。结论 Ａｓ２Ｏ３ 可以破坏卵母细胞的成熟、降低卵母细胞的受精能力， 对生殖细胞和生育能力有一定的毒性作用。
Objective To investigate the effects of arsenic trioxide (As2O3) on reproductive performance in mice. Methods The in vitro fertilization and in vitro fertilization of mouse oocytes were used to study the effects of As2O3 on oocyte maturation and in vitro fertilization. Results As2O3 had no effect on the number of oocyte ruptured and superovulated oocytes in mice, but inhibited the release of the first polar body and reduced the in vitro fertilization rate and the survival rate of oocytes. Conclusion As2O3 can destroy the maturation of oocytes, reduce the ability of oocytes to fertilize, and have certain toxic effects on germ cells and fertility.