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目的:讨论类风湿因子(RF)、C反应蛋白(CRP)和抗环瓜氨酸肽(抗-CCP)抗体的检测对诊断类风湿关节炎(RA)的临床辅助诊断的作用。方法应用速率散射比浊法测定CRP、RF,应用ELISA法测定抗-CCP抗体。结果:85例病人中,RF灵敏度为73.24%,特异性分别46.33%,CRP灵敏度为86%特异性分别36%,抗-CCP抗体灵敏度为74%,特异性分别96%,3项联合检测灵敏度为97%,特异性23%。结论:RF、CRP和抗-CCP抗体在病例组和对照组中有显著差异,对诊断类风湿性关节炎提供了很大的帮助。3者结合起来为临床诊断提供更为有价值的资料。
OBJECTIVE: To investigate the role of rheumatoid factor (RF), C-reactive protein (CRP) and anti-cyclic citrullinated peptide (anti-CCP) antibodies in the clinical diagnosis of rheumatoid arthritis (RA). Methods The rate nephelometry (CRP) and radioimmunoassay (RF) were used to measure anti-CCP antibody by ELISA. Results: In 85 patients, the sensitivity of RF was 73.24%, specificity was 46.33%, specificity of CRP was 86%, specificity of anti-CP antibody was 74%, specificity was 96%, sensitivity of three combined detection 97%, specificity 23%. Conclusion: RF, CRP and anti-CCP antibodies in the case group and control group were significantly different, the diagnosis of rheumatoid arthritis has provided a great help. 3 combined to provide more valuable information for clinical diagnosis.