顺－２－丁稀－１，４－二醇的１，４－二羟基被邻二苯甲基保护形成环烯２、然后氧化生成σ－对称十员氧杂环－１，２－二醇３，将３转化为单三甲基硅醚４后，在三氟甲磺酸三甲基硅酯（ＴＭＳＯＴｆ）的催化下，与Ｃ２－对称二亚砜手性辅助试剂１进行缩酮化反应得到光学活性缩酮５，随后的碱催化缩酮开裂反应非对映选择性大于９９％。最后，水解去掉手性辅助试剂，以良好的产率和９５％ｅｅ的光学纯度得到光学活性醇７。 The 1,4-dihydroxy group of cis-2-butane-1,4-diol is protected by ortho-benzhydryl to form cycloalkene 2 which is then oxidized to form a σ-symmetrical ten-membered oxacyclo-1,2-diol 3, after the conversion of 3 into monomethylsilylene 4, the ketalization reaction with the C2-symmetrical disulfide chiral auxiliary reagent 1 is carried out under the catalysis of trimethylsilyl trifluoromethanesulfonate (TMSOTf) The optically active ketal 5 is obtained, with subsequent base catalyzed ketal cleavage diastereoselectivity of greater than 99%. Finally, the chiral auxiliary reagent is removed by hydrolysis to give optically active alcohol 7 in good yield and optical purity of 95% ee.