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为研究细胞因子白细胞介素－６（ＩＬ－６）和肿瘤坏死因子α（ＴＮＦα）与老年肺癌病情和预后的关系，采用ＥＬＩＳＡ法检测了４０例老年肺癌患者血清ＩＬ－６和ＴＮＦα的水平。结果表明：１．老年肺癌患者血清ＩＬ－６和ＴＮＦα水平随着临床分期的进展而升高；有远处转移的晚期患者的血清ＩＬ－６和ＴＮＦα水平明显高于无转移的早期患者；２．化疗有效、病情稳定和缓解的患者血清ＩＬ－６和ＴＮＦα水平明显下降；化疗无效、病情进展者血清ＩＬ－６和ＴＮＦα的水平则升高；３．患者死亡前３个月内血清ＴＮＦα水平有持续升高的趋势。提示ＩＬ－６和（或）ＴＮＦα水平的升高可作为老年肺癌病人预后不良和病情进展的指标。
To investigate the relationship between cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα) and the disease status and prognosis of elderly lung cancer, the serum levels of IL-6 and TNFα in 40 elderly patients with lung cancer were detected by ELISA. The results show that: 1. The serum levels of IL-6 and TNFα in elderly patients with lung cancer increased with the progression of clinical stages. The levels of serum IL-6 and TNFα in patients with distant metastasis were significantly higher than those without metastasis. The levels of serum IL-6 and TNFα in patients with effective chemotherapy, stable and remission of disease were significantly decreased, and the levels of serum IL-6 and TNFα in patients with chemotherapy-ineffective and disease progression were increased. Serum TNFα levels continued to increase during the first 3 months after death. This suggests that elevated levels of IL-6 and/or TNFα may serve as an indicator of poor prognosis and progression of disease in older lung cancer patients.