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目的探讨膀胱癌非肿瘤黏膜表皮生长因子受体(EGFR)表达与膀胱癌预后的关系。方法1998-2004年原发性膀胱癌患者非肿瘤黏膜组织标本64例,标本均为距癌组织至少3cm以上病理证实为正常膀胱黏膜;另6例正常膀胱黏膜均取自良性前列腺增生手术患者。采用S-P免疫组化染色,对检测结果进行统计学分析处理(χ2检验)。结果随膀胱肿瘤病理分级增加,EGFR表达阳性表达率增高,Ⅲ级明显高于Ⅰ级和Ⅱ级(χ2=6.22,P<0.05);EGFR表达随肿瘤临床分期的增加阳性表达率也增高,但差异无统计学意义(χ2=2.08,P>0.05);复发性肿瘤EGFR阳性表达率明显高于未复发者,差异有统计学意义(χ2=4.95,P<0.05)。结论膀胱癌患者非肿瘤黏膜EG-FR表达较正常黏膜明显增强。EGFR在膀胱黏膜的异常表达可能早于癌细胞的出现,EGFR在膀胱肿瘤的发生、发展起着重要作用,可作为早期判断预后因子。
Objective To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) and the prognosis of bladder cancer. Methods From 1998 to 2004, 64 cases of non-tumorous mucosa specimens from patients with primary bladder cancer were examined. The specimens were normal bladder mucosa at least 3cm away from the cancer and the other 6 normal bladder mucosa were both from benign prostatic hyperplasia patients. S-P immunohistochemical staining, the test results were statistically analyzed (χ2 test). Results The positive expression rate of EGFR increased with the increase of the pathological grade of bladder neoplasm. The grade Ⅲ was significantly higher than that of grade Ⅰ and Ⅱ (χ2 = 6.22, P <0.05). The expression of EGFR was also increased with the increase of clinical stage The difference was not statistically significant (χ2 = 2.08, P> 0.05). The positive rate of EGFR in recurrent tumors was significantly higher than that in non-recurrent tumors (χ2 = 4.95, P <0.05). Conclusion The expression of EG-FR in non-tumor mucosa of bladder cancer patients was significantly higher than that of normal mucosa. The abnormal expression of EGFR in the bladder mucosa may be earlier than the appearance of cancer cells. EGFR plays an important role in the occurrence and development of bladder cancer and can be used as an early prognostic factor.