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治疗药物监测(therapeutic drug monitoring,TDM):是指在临床进行药物治疗过程中,观察药物疗效的同时定时采集患者的血液(有时采集尿液、唾液等液体),测定其中的药物浓度,探讨药物的体内代谢过程,以便根据患者的具体情况,以药动学和药效学基础理论为指导,借助先进的分析技术与电子计算机手段,并利用药动学原理和公式,使给药方案个体化,从而达到满意的疗效并避免发生不良反应,同时也可以为药物过量中毒的诊断和处理提供有价值的实验室依据,将临床用药从传统的经验模式提高到比较科学的水平。
Treatment drug monitoring (therapeutic drug monitoring, TDM): refers to the clinical medication during the observation of drug efficacy at the same time regularly collect the patient’s blood (and sometimes collected urine, saliva and other liquids), determine the concentration of the drug to explore the drug In vivo metabolic process, according to the patient’s specific situation, in order to pharmacokinetics and pharmacodynamics of basic theory as a guide, with advanced analytical techniques and computerized means, and the use of pharmacokinetic principles and formulas, the drug program individualized , So as to achieve satisfactory curative effect and avoid adverse reactions. At the same time, it can also provide a valuable laboratory basis for the diagnosis and treatment of drug overdose poisoning, and improve clinical medication from the traditional experience mode to a more scientific level.