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本实验以１２５Ｉ－ＬＰＳ对大鼠灌胃后，观察腹膜炎大鼠肠源性内毒素移位后各脏器中分布。结果表明：急性感染性腹膜炎可致肠源性内毒素移位增加，各重要脏器中均含不同浓度的内毒素，内毒素含量由高至低为：肾、肺、肝、胰、肠系膜淋巴结、心脏（Ｐ＜０．０５）。大承气汤能明显抑制腹膜炎大鼠肠源性内毒素移位（Ｐ＜０．０１），并可增加１２５Ｉ－ＬＰＳ的粪便排出量（Ｐ＜０．０１）。为临床治疗肠源性内毒素血症提供了一个可靠的方法。
In this experiment, 125I-LPS was administered intragastrically to rats, and the distribution of enterotoxin in peritonitis rats was observed. The results showed that: acute infectious peritonitis can cause increased translocation of intestinal endotoxin, all the major organs contain different concentrations of endotoxin, endotoxin levels from high to low as: kidney, lung, liver, pancreas, mesenteric lymph nodes , Heart (P <0.05). Dachengqi Decoction can significantly inhibit the intestinal endotoxin translocation in rats with peritonitis (P <0.01), and increase the excretion of 125I-LPS feces (P <0.01). For clinical treatment of intestinal endotoxemia provides a reliable method.