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目的:探讨联合测定不同病因胸腔积液中分泌型白细胞蛋白酶抑制因子(SLPI)、干扰素-γ(IFN-γ)和腺苷脱氨酶(ADA)的浓度对结核性胸腔积液的诊断价值。方法 :收集93例胸腔积液及其同源外周血,分为结核组、恶性组、细菌感染组及漏出液组。测定三种指标浓度,并对结果及意义进行分析。结果:结核组胸水SLPI、IFN-γ及ADA浓度较恶性组、感染组及漏出液组比较有统计学差异(P<0.05)。受试者工作特征曲线(ROC曲线)结果显示SLPI、IFN-γ和ADA对于诊断结核性胸腔积液均具有较高诊断效能;联合SLPI、IFN-γ和ADA能提高结核性胸腔积液诊断效能,其中以三者联合诊断效能最佳。结论:单独测定SLPI、IFN-γ及ADA均有助于诊断结核性胸腔积液,但联合测定更能提高诊断效能。
Objective: To investigate the diagnostic value of combined determination of the concentration of secretory leukocyte protease inhibitor (SLPI), interferon-γ (IFN-γ) and adenosine deaminase (ADA) in pleural effusion of different etiology in the diagnosis of tuberculous pleural effusion . Methods: Ninety-three pleural effusion and its homologous peripheral blood were collected and divided into tuberculosis group, malignant group, bacterial infection group and leakage group. Determination of three indicators of concentration, and the results and significance analysis. Results: The pleural fluid SLPI, IFN-γ and ADA concentrations in tuberculosis group were significantly higher than those in malignant group, infection group and leaking fluid group (P <0.05). The receiver operating characteristic curve (ROC curve) showed that SLPI, IFN-γand ADA had high diagnostic value in the diagnosis of tuberculous pleural effusion. Combination of SLPI, IFN-γ and ADA could improve the diagnostic efficacy of tuberculous pleural effusion , Of which three combined diagnosis of the best performance. Conclusion: The determination of SLPI, IFN-γ and ADA alone can be helpful in the diagnosis of tuberculous pleural effusion, but the combination of test can improve the diagnostic efficacy.