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儿童哮喘对吸入常规剂量的皮质类固醇治疗一般反应良好,但有时却需要大剂量(>400μg/d)方能奏效。哮喘患儿吸入常规剂量的皮质类固醇对肾上腺功能的影响甚小,而大剂量吸入有无影响尚不十分清楚。为评价大剂量吸入皮质类固醇对肾上腺功能的影响,作者对重症持续哮喘患儿长期用药后清晨血浆皮质醇浓度作了测定,并且进行了短程合成促皮质素兴奋试验。 临床资料 治疗组77例,其中吸入布的松者49例.年龄4～16岁,平均9.2岁,每日用药量800～2400μg,用药时间9～96个月,平均29.9个月;吸入丙
Childhood asthma generally responds well to inhalation of conventional doses of corticosteroids, but sometimes requires large doses (> 400 μg / d) to work. Inhaled asthma children with conventional doses of corticosteroids have little effect on adrenal function, but whether the impact of high-dose inhalation is not yet very clear. In order to evaluate the effect of high-dose inhaled corticosteroids on adrenal function, the authors measured plasma cortisol concentrations in early morning after long-term medication in children with severe persistent asthma and conducted a short-range synthetic corticotropin-stimulating test. Clinical data The treatment group of 77 patients, including inhaled cloth pine in 49 cases, aged 4 to 16 years, mean 9.2 years, the daily dose of 800 ~ 2400μg, medication for 9 to 96 months, an average of 29.9 months; inhaled C