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在合成二烃基丙二酸酯时,两个烃基进去的先后次序十分重要,仲烃基进入伯烃基丙二酸酯分子中,要比伯烃基进入仲烃基丙二酸酯分子中容易得多。后者在一般条件下是不能实现的,或虽实现了但产率很低。前一工作曾报导了通式为R—CH—CH_3—C—R’(COOC_2H_5)_2(R=C_3H7,异—C_3H_7,C_6H_5,邻—CH_3C_6H_4,R’=CH_3)的二烃基丙二酸二乙酯的合成及其皂化反应的研究。证明了在叔丁醇钠存在下,以叔丁醇作溶剂,向带多侧链仲烃基丙二酸二乙酯引入一个甲基,得到了良好的结果,其产率为55—75%。并且发现所得到的二烃基丙二酸酯很难
In the synthesis of dihydrocarbyl malonates, the order of the two hydrocarbyl groups is very important. It is much easier for the secondary hydrocarbyl groups to enter the primary hydrocarbylmalonate molecule than to enter the secondary hydrocarbylmalonate molecule. The latter can not be achieved under normal conditions, or it is achieved but the yield is very low. The previous work reported the synthesis of dihydrocarbylmalonic acid di (2-alkylmalonic acid) of the general formula R-CH-CH 3-C-R ’(COOC_2H_5) _2 (R = C_3H7, iso-C_3H_7, C_6H_5, ortho-CH_3C_6H_4, R’ = CH_3) Synthesis of Ester and Its Saponification Reaction. It has been demonstrated that the introduction of a methyl group to the multi-side chain diethylhydrocarbylmalonate in the presence of t-butanol as a solvent in the presence of t-butoxide yields good results in 55-75% yield. And found that the resulting dialkylmalonate is difficult