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目的:探讨来曲唑与二甲双胍治疗多囊卵巢综合征的临床效果及对患者血清胃生长素(ghrelin)、性激素及血脂水平的影响。方法:选择多囊卵巢综合征患者90例,均于2014年7月至2016年7月在本院接受治疗。根据治疗方法不同,将所选研究对象分为研究组与对照组,每组45例。对照组患者采用盐酸二甲双胍治疗,研究组患者在对照组基础上采用来曲唑片治疗。观察并比较两组患者治疗前后血清胃生长素(ghrelin)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)及高密度脂蛋白(HDL-C)水平,以及临床疗效。结果:研究组患者临床总有效率(88.9%)高于对照组(71.1%),差异具有统计学意义(P<0.05);两组患者治疗后血清ghrelin水平均升高,且研究组高于对照组,差异具有统计学意义(P<0.05);两组患者治疗后血清LH,E2及T水平均降低,且研究组低于对照组,差异具有统计学意义(P<0.05);两组患者治疗后血清FSH水平比较,差异无统计学意义(P>0.05);治疗后两组患者血清HDL-C水平均升高,且研究组高于对照组,差异具有统计学意义(P<0.05);治疗后两组患者血清LDL-C,TC及TG水平均降低,且研究组低于对照组,差异具有统计学意义(P<0.05)。结论:来曲唑联合二甲双胍治疗多囊卵巢综合征具有明显的临床效果,不仅可以改善患者卵巢功能及高雄激素状态,还能缓解患者高血脂症状,值得临床推广应用。
Objective: To investigate the clinical effects of letrozole and metformin in treatment of patients with polycystic ovary syndrome and its effect on serum ghrelin, sex hormone and blood lipid levels. Methods: Ninety patients with polycystic ovary syndrome were selected and treated in our hospital from July 2014 to July 2016. According to different treatment methods, the selected subjects were divided into study group and control group, with 45 cases in each group. Patients in the control group were treated with metformin hydrochloride. Patients in the study group were treated with letrozole on the basis of the control group. The levels of serum ghrelin, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) levels, as well as clinical efficacy. Results: The total clinical effective rate (88.9%) in study group was higher than that in control group (71.1%), the difference was statistically significant (P <0.05); serum ghrelin levels increased after treatment in both groups, (P <0.05). The levels of serum LH, E2 and T decreased after treatment in both groups, and the difference between the two groups was statistically significant (P <0.05). There was no significant difference between the two groups There was no significant difference in the level of serum FSH between the two groups after treatment (P> 0.05). The levels of serum HDL-C in both groups increased after treatment, and the difference between the two groups was statistically significant (P <0.05 ). Serum levels of LDL-C, TC and TG were decreased in both groups after treatment, and the study group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion: Letrozole combined with metformin in the treatment of PCOS has obvious clinical effect, which can not only improve ovarian function and hyperandrogenism, but also relieve the symptoms of hyperlipidemia in patients. It is worthy of clinical application.