前列腺特异性抗原(Proctate specific antigen,PSA)是当前诊断和处理前列腺癌极有价值的瘤标,其命名旨在强调其组织器官特异性。过去一直认为只有前列腺的上皮细胞才能产生PSA,因为早期应用免疫组织化学或免疫方法发现它仅存在于正常的或恶性前列腺组织中,由于PSA具有重要的临床价值,这使得对其研究在近10年中取得了重大进展。目前认为PSA不仅存在于前列腺组织中,而且也存在于非前列腺组织中,本文就其非特异性方面的研究情况做一综述。 Proct specific antigen (PSA) is an extremely valuable tumor marker for the diagnosis and treatment of prostate cancer. Its nomenclature aims to emphasize its tissue and organ specificity. In the past, it was thought that only prostate epithelial cells produce PSA because early application of immunohistochemistry or immunological methods found that it is only present in normal or malignant prostate tissue. Because PSA has important clinical value, it makes its research in the near 10 Significant progress was made during the year. PSA is currently considered not only in prostate tissue, but also in non-prostate tissue, this paper reviews its non-specific aspects of the study.