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目的观察服用三唑仑对汽车兵夜间睡眠质量和次日汽车驾驶能力的影响,为今后在飞行人员中应用提供试验依据。方法 60名男性汽车兵随机分为安慰剂组和三唑仑组(各组n=30)。试验第1日8:30和14:30各完成1次考核场汽车驾驶任务,在夜间0:00两组分别服用药物(三唑仑0．25 mg或安慰剂)后睡眠5．5 h,于次日7:00、10:00、13:00和16:00(用药后7-16 h)完成4次相同的驾驶任务,测定指标包括:主观睡眠质量、斯坦福嗜睡量表和自认疲劳分级量表评分,考核场汽车驾驶成绩,视听反应能力和临界闪光融合频率。结果与安慰剂组相比,三唑仑组的主观睡眠质量明显提高,而汽车驾驶成绩、视听反应能力和闪光融合频率两组无明显差异。结论常规单剂量服用三唑仑具有提高汽车兵睡眠质量的效果,用药7 h后对汽车驾驶能力无明显不良影响。
Objective To observe the effects of taking triazolam on the nighttime sleep quality of motorized soldiers and the driving ability of the next day, and provide the experimental basis for the future application among pilots. Methods Sixty male car soldiers were randomly assigned to placebo and triazolam (n = 30 in each group). At 8:30 and 14:30 on the first day of the trial, each examination field vehicle driving task was completed. At night, the two groups took drugs (0.25 mg triazolam or placebo) and then slept for 5.5 hours at 0:00. The same driving task was completed 4 times at 7:00, 10:00, 13:00 and 16:00 (7-16 h after dosing) on the following day. The measurement indicators included: subjective sleep quality, the Stanford Sleepiness Scale and self-inflicted fatigue Grading scale scores, test car driving performance, audio-visual response and critical flash fusion frequency. Results Compared with the placebo group, the subjective sleep quality of the triazolam group was significantly improved, while the driving performance, audio-visual response ability and flash fusion frequency had no significant difference between the two groups. Conclusion The conventional single-dose triazolam has the effect of improving the quality of automobile soldier’s sleep quality. After 7 h of medication, there is no obvious adverse effect on car driving ability.