异丁基哌嗪力复霉素(R-76-1)系力复霉素类新衍生物,四川抗菌素工业研究所半合成研究室于1976年研制成功,1978年后与四川长征制药厂、无锡第一制药厂协作进行工艺研究,并生产了部分样品供临床试用。根据临床前药理研究证明R-76-1对结核杆菌及麻疯杆菌具有与利福平相似或稍强的抗菌作用,毒性低,吸收好,用利福平1/3剂量治疗322例结核病,其近期疗效达到与利福平同等优良效果,而且毒副反应小。在抗痨 Isobutylpiperazine rifamycins (R-76-1) Department of microrubicin new derivatives, Sichuan Institute of antibiotics semi-synthetic laboratory successfully developed in 1976, after 1978 and Sichuan Changzheng Pharmaceutical Factory, Wuxi No. 1 Pharmaceutical Factory collaborated in process research and produced some samples for clinical trial. According to preclinical pharmacological studies, R-76-1 has similar or slightly stronger antibacterial activity against Mycobacterium tuberculosis and Mycobacterium leprae with rifampicin, low toxicity and good absorption, and 322 cases of tuberculosis were treated with 1/3 of rifampicin, The immediate effect of rifampin to achieve the same excellent results, and the side effects of small. In the anti-痨