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目的对脑梗死急性期降压治疗对近期及远期预后的影响进行观察。方法 144例脑梗死急性期患者,随机分为观察组与对照组,各72例。对照组给予脑梗死常规治疗,并在入院后第7天开始给予降压治疗;观察组在常规治疗基础上于患者入院后开始给予持续动态血压监测6 d,并在入院后次日针对血压变化情况给予处理。比较两组的治疗效果。结果观察组入院第6天血压明显低于第1天(P<0.05)。观察组患者入院第7天和治疗3个月心脑血管事件发生率(5.56%、8.33%)均明显低于对照组(18.06%、20.83%)(P<0.05)。治疗第7天观察组与对照组致残率及死亡率比较差异均无统计学意义(P>0.05);治疗后3个月观察组致残率低于对照组,差异有统计学意义(P<0.05),两组治疗后3个月死亡率比较差异无统计学意义(P>0.05)。结论对脑梗死急性期患者及时进行血压干预治疗对患者近期及远期预后都有明显的改善作用。
Objective To observe the effect of antihypertensive therapy in acute stage of cerebral infarction on short-term and long-term prognosis. Methods 144 cases of acute cerebral infarction patients were randomly divided into observation group and control group, each 72 cases. The control group was given routine treatment of cerebral infarction and started antihypertensive treatment on the 7th day after admission. The observation group received continuous ambulatory blood pressure monitoring 6 days after admission on the basis of routine treatment, and on the day after admission, The situation is dealt with. Compare the treatment effect of two groups. Results On the sixth day after admission, the blood pressure in observation group was significantly lower than that on the first day (P <0.05). The incidence of cardiovascular and cerebrovascular events on the 7th day and 3 months after treatment in the observation group (5.56%, 8.33%) were significantly lower than those in the control group (18.06%, 20.83%, P <0.05). There was no significant difference in morbidity and mortality between the observation group and the control group on the 7th day after treatment (P> 0.05). The morbidity of the observation group at 3 months after treatment was lower than that of the control group (P <0.05). There was no significant difference in mortality at 3 months after treatment between the two groups (P> 0.05). Conclusion The timely treatment of blood pressure in patients with acute cerebral infarction has a significant effect on the short-term and long-term prognosis of patients.