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黏膜组织由上皮细胞和其上覆盖的一层黏液组成,构成了蛋白类药物口服吸收的屏障。在载有胰岛素的三甲基壳聚糖(TMC)纳米粒表面包裹一层亲水性材料N-(2-羟丙基)甲基丙烯酰胺共聚物(p HPMA),可促进纳米粒穿透黏液层到达上皮细胞表面,并且p HPMA分子在纳米粒穿透黏液层后就开始分离。此时,暴露在上皮细胞表面的TMC纳米粒核通过旁细胞途径进行跨上皮转运。试验表明,p HPMA能显著改善TMC纳米粒的跨上皮转运,并增强TMC纳米粒打开黏液分泌型上皮
Mucosal tissue consists of epithelial cells and a layer of mucus overlying it, forming a barrier for the oral absorption of protein drugs. The hydrophilic nanoparticles of N- (2-hydroxypropyl) methacrylamide (p HPMA) were coated on the surface of insulin-loaded trimethylchitosan (TMC) nanoparticles to promote nanoparticle penetration The mucus layer reaches the surface of the epithelial cells, and p HPMA molecules begin to separate after the nanoparticle has penetrated the mucus layer. At this point, the TMC nanoparticle nuclei exposed on the surface of the epithelial cells transmembrane transport through the paracellular pathway. Experiments show that p HPMA can significantly improve transmembrane transport of TMC nanoparticles and enhance the opening of mucosal secretory epithelium