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应用放射免疫法及 HCV- RNA NS5 酶切分型法检测 48例慢性丙型肝炎患者血清中 IL - 2、TNF及 HCV基因型 ,并以 2 0例健康人为正常对照。结果显示 :HCV基因型 型的慢性丙型肝炎干扰素疗效 (显效率 2 3% )差于 型(显效率 80 % ) (P<0 .0 5 ) ;慢性丙型肝炎患者干扰素治疗无效组 IL- 2水平 [(2 .5 3± 0 .5 7) ng/ ml]低于显效组 [(3.6 8± 0 .84) ng/ ml](P<0 .0 5 ) ;慢性丙型肝炎患者干扰素治疗显效组 TNF水平 [(3.15± 0 .77) ng/ ml]与无效组[(3.47± 1.10 ) ng/ ml]相仿 (P>0 .0 5 )。提示 :HCV基因型及 IL - 2可能影响干扰素的疗效 ;TNF不影响干扰素的疗效。
Serum IL - 2, TNF and HCV genotypes of 48 patients with chronic hepatitis C were detected by radioimmunoassay and HCV - RNA NS5 restriction enzyme digestion. Twenty healthy controls were used as controls. The results showed that: HCV genotype of chronic hepatitis C interferon curative effect (significant efficiency of 23%) was worse than type (markedly effective rate of 80%) (P <0.05); interferon therapy in patients with chronic hepatitis C ineffective group The level of IL-2 was lower than that of the patients in the effective group [(3.6 8 ± 0.84) ng / ml] (P <0.05) The level of TNF in patients with interferon therapy was significantly higher than that in the control group [(3.15 ± 0.77) ng / ml vs [3.47 ± 1.10) ng / ml] (P> 0.05). Tip: HCV genotype and IL - 2 may affect the efficacy of interferon; TNF does not affect the efficacy of interferon.