慢性肾脏病(CKD)患者约占世界总人口10%[1]。全球人口老龄化以及糖尿病、高血压、肥胖等疾病发病率增高导致CKD发病率逐年上升。肾纤维化是CKD发展至终末期的最终结果,其特征包括肾小球硬化和小管间质纤维化。无论基础疾病如何,CKD一旦持续进展终将导致肾组织广泛瘢痕形成,表现 Chronic kidney disease (CKD) patients account for about 10% of the world’s population [1]. The global population aging and diabetes, hypertension, obesity and other diseases increased incidence of CKD led to a rising incidence year by year. Renal fibrosis is the end result of CKD progression to end-stage and is characterized by glomerulosclerosis and tubulointerstitial fibrosis. Regardless of underlying disease, CKD, once sustained, will eventually lead to extensive scarring of the kidney