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分别以4种酚类化合物:2-甲基苯酚、邻苯二酚、间苯二酚、对苯二酚为反应物,首先将反应底物的羟基进行甲基或者甲氧基甲基保护,然后将所得到的产物在醋酸溶剂中,以溴化钾和过氧化氢为试剂,钼酸铵为催化剂的条件下,研究了在苯环骨架上引入了溴原子的方法.研究结果表明,实验方法操作简单易行,反应时间较短,产物专一性好,后处理简单,并且收率较高,活化溴原子对苯环的进攻位置主要受到催化剂钼酸大分子结构的控制.产物经红外光谱和核磁共振谱进行了结构表征,证实成功合成了目标化合物.
Four kinds of phenolic compounds, 2-methylphenol, catechol, resorcinol and hydroquinone were used as reactants. The hydroxyl groups of the reaction substrates were protected by methyl or methoxymethyl, Then, the obtained product was studied in the acetic acid solvent, potassium bromide and hydrogen peroxide as reagents and ammonium molybdate as catalyst to introduce the bromine atom into the benzene ring skeleton.The results show that the experiment The method is easy to operate, the reaction time is short, the product specificity is good, the post-treatment is simple, and the yield is high. The attack position of the activated bromine atom on the benzene ring is mainly controlled by the catalyst molybdate macromolecule structure. The structures were characterized by UV-vis spectra and nuclear magnetic resonance spectroscopy, confirming the successful synthesis of the target compound.