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目的考察瑞香素大鼠在体肠吸收动力学特征。方法对大鼠小肠段的十二指肠、空肠、回肠、结肠4个部位及整段小肠分别进行在体肠吸收实验,比较瑞香素在各肠段的吸收参数。结果在0.024~0.096 mg/mL浓度范围内瑞香素在小肠的吸收量与浓度有良好线性关系(r=0.9999),药物在各肠段的吸收速率从十二指肠到结肠有所增加,但Ka值基本不变。结论瑞香素在大鼠小肠各段均有吸收,在肠道内的吸收呈现一级吸收动力学特征,吸收机制为被动扩散。
Objective To investigate the kinetic characteristics of in vivo intestinal absorption of daphnetin in rats. Methods Intestinal absorption experiments were performed on the duodenum, jejunum, ileum, and colon of the small intestine of the rat, and whole intestinal absorption was compared. The absorption parameters of daphnetin in each intestine were compared. Results There was a good linear relationship between the absorption and concentration of daphnetin in the small intestine in the concentration range of 0.024~0.096 mg/mL (r=0.9999). The absorption rate of the drug in the intestine increased from the duodenum to the colon, but The Ka value is basically unchanged. Conclusion Daphnetin is absorbed in every segment of the small intestine of rats and its absorption in the intestine shows a primary absorption kinetics. The absorption mechanism is passive diffusion.