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目的研究牡丹江地区II型糖尿病与A;;CE基因多态的相关性。方法采用PCR-RFLP技术,对牡丹江汉族II糖尿病患者、正常人的A;;CE基因多态性检测,观察基因型频率及等位基因频率。结果 II型糖尿病组II、ID、DD基因型频率分别为65.5%、26.4%、8.0%;I及D等位基因频率分别为78.7%、21.3%。正常对照组II、ID、DD基因型频率分别为35.0%、55.0%、10.0%;I及D等位基因频率分别为62.5%、37.5%。两组之间基因型频率及等位基因频率差异有统计学意义(P<0.01)。结论 A;;CE基因多态性与牡丹江地区的II型糖尿病发生有相关性。
Objective To study the association between type II diabetes mellitus and A ;; CE gene polymorphism in Mudanjiang. Methods PCR-RFLP was used to detect the polymorphism of A ;; CE gene in Han nationality II diabetes mellitus patients and normal controls in Mudanjiang. The genotype frequency and allele frequency were observed. Results The frequencies of genotypes II, ID and DD of type II diabetes patients were 65.5%, 26.4% and 8.0%, respectively. The frequencies of I and D alleles were 78.7% and 21.3%, respectively. The frequencies of genotypes II, ID and DD in normal control group were 35.0%, 55.0% and 10.0%, respectively. The frequencies of I and D allele were 62.5% and 37.5% respectively. There was a significant difference in genotype frequency and allele frequency between the two groups (P <0.01). Conclusion A ;; CE gene polymorphism and type M diabetes in Mudanjiang have a correlation.