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在器官移植术 ,心肌梗死、脑梗死后溶栓术 ,冠脉搭桥术、经皮腔内冠脉成形术等术后面临的缺血再灌注损伤 (IRI)是临床的一个重要课题 ,IRI早期血管内皮细胞 (EC)结构和功能的严重损伤是构成IRI病理生理过程的基础。目前研究认为 ,预适应对EC有保护作用 ,其作用机制非常复杂 ,涉及多种因素。预适应的方式有多种 ,其中药物预适应易行有效且便于控制剂量 ,已引起人们关注。
Ischemia-reperfusion injury (IRI), such as organ transplantation, myocardial infarction, thrombolysis after cerebral infarction, coronary artery bypass grafting and percutaneous transluminal coronary angioplasty, is an important clinical issue. In the early stage of IRI Serious damage to the structure and function of vascular endothelial cells (ECs) underlies the pathophysiology of IRI. The current study suggests that preconditioning has a protective effect on EC and its mechanism of action is very complex and involves a variety of factors. Pre-adapt a variety of ways, including drug pre-acclimation easy and effective and easy to control the dose, has drawn people’s attention.