维甲酸(Retinoic acid下称RA)类化合物是一类天然或合成的具有维生素A结构或活性的化合物,在人体内具有多种生物学功能。近年来发现,RA对早幼粒细胞白血病、宫颈的鳞癌和皮肤转移性鳞癌等有治疗作用,引起了研究者的关注。本文对近年来用RA抗实体瘤作用的研究及可能机制作一综述。 1 RA类化合物的理化特性 维生素A在人体内不能合成,需从食物中摄取。蔬菜中的β胡萝卜素和动物组织中的维生素A酯大部分需在肠腔内转化成维生素A后才能被肠上皮细胞吸收,然后经过酯化过程形成维生素A酯,随乳糜微粒进入并贮存于肝脏。部 Retinoic acid (hereinafter referred to as RA) compounds are natural or synthetic compounds having a vitamin A structure or activity and have a variety of biological functions in the human body. In recent years, it has been found that RA has a therapeutic effect on promyelocytic leukemia, squamous cell carcinoma of the cervix and metastatic squamous cell carcinoma of the cervix, which has attracted the attention of researchers. This article reviews the recent studies on the role of RA against solid tumors and possible mechanisms. 1 Physicochemical properties of RA compounds Vitamin A cannot be synthesized in the human body and needs to be taken from food. Most of the β-carotene in vegetables and vitamin A esters in animal tissues need to be converted into vitamin A in the intestine before they can be absorbed by intestinal epithelial cells. After esterification, vitamin A esters are formed, and they enter and store in the chylomicrons. liver. unit